The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery.
This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories. Routes of Ocular Drug Delivery - Conventional vs. Drug Delivery to Anterior Segment of the Eye. Jwala Renukuntla, Sujay J.
Biodegradable Polymers for Ophthalmic Applications. Novel Strategies to Enhance Ocular Bioavailability. Application of Nanotechnology in Ocular Drug Delivery. Bioavailability to the anterior segment of the eye remains low from topical administration despite decades of research. In fact, the challenges to ocular drug delivery are becoming exponentially greater with therapies directed towards posterior segment diseases and a much broader palette of drug substances to be delivered.
The present eBook not only covers these issues in significant detail, but the leading experts in the field authored the chapters. The present eBook offers an integrated understanding of anatomy and physiology, disease state, drug absorption and disposition and drug delivery. The first five chapters of the eBook lay the foundation for ocular drug delivery and the current state of the art. Chapter 1 nicely deals with the anatomic and physiologic constraints to drug delivery. Chapter 2 explores delivery beyond conventional topical and systemic approaches.
Taking advantage of non-conventional routes of delivery minimizes some of the issues with conventional topical therapy including tear dilution, rapid precorneal drainage and may also buffer systemic absorption to some extent. Additionally, these novel routes offer new and novel opportunities for sustained and controlled delivery to the eye.
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This chapter differentiates conventional and novel routes and discusses their relative merits. Chapters 3 and 4 deal with anterior and posterior segment drug delivery, respectively. The various attempts to improve anterior segment drug delivery are described. Static and dynamic barriers to drug delivery are discussed.
Treatise on Ocular Drug Delivery
A decade ago little consideration was given to the dynamic barriers to penetration as well as the role of enzymes and transporters in posterior segment drug delivery. The field is just now realizing the impact of these factors and Chapter 4 describes these critical and newly defined variables. Specific strategies for achieving effective drug delivery to the eye are detailed in Chapter 5 through 7 and Chapter In Chapter 5, biodegradable polymers for drug delivery are reviewed. This class of polymers represents a significant component of many posterior segment drug delivery strategies.
This is a crucial chapter for anyone interested in ocular drug delivery.
Drug delivery in a broader context is dealt with in chapter 6 and includes erodible and non-erodible systems. Implants, microspheres, liposomes and semi-solids as well as more complex delivery systems are discussed. These strategies have been shown to be effective in circumventing many of the barriers to ocular absorption, but none are without potential side effects. Chapter 7 addresses enhancing the permeation of these barriers, rather than circumvention, through techniques such as ultrasound, microneedles and prodrug modification.
Treatise on Ocular Drug Delivery:: volume 1 | BenthamScience
The next two chapters cover critical areas for the field. The eye is not readily amenable to serial sampling and as such it is difficult to reasonably power ocular pharmacokinetic studies. Microdialysis as a tool to address the limitations of classic ocular pharmacokinetic techniques is discussed in Chapter 8.
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