Advances in Immunology: 50


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Innate immunity 2018

Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming.

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However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health. Controlling diseases, through better preventative and treatment methods requires a detailed understanding of the immune response in livestock species.

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Multiple studies have identified associations between variation in immune genes and disease susceptibility, which potentially opens up new avenues to select animals with superior disease resistance. Detailed understanding of immunity in cattle is leading to the design of more effective vaccines.

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What has happened in the last 50 years in immunology.

Furthermore, appreciation of the significant differences between rodent and human immune responses has also led to bovine models being developed for some human diseases. The publication of the bovine genome and the advent of next-generation sequencing technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. As a result there has been an explosion of exciting research findings including in metagenomics and epigenetics.

Recently, there has been a welcome move to integrate our emerging understanding of the immune response with detailed studies of other important physiological processes including nutrition and reproduction. The interactions between the reproductive system, nutrition and the immune system are of particular interest, since each places significant demands on the animal at various stages through the production cycle.

The interplay between these morphologically diffuse systems involves widely distributed chemical signals in response to environmental input, and each system must interact for the normal functioning of the other.

NEI 50th Anniversary Symposium Slideshow: Vision and Immunology

Immunoglobulin preparations for the treatment of antibody deficiencies improved with the development of preparations for intravenous then subcutaneous administration, giving patients choice and the ability for home-based treatment, especially if experiencing infusion associated adverse effects. Newborn screening for severe combined immunodeficiency is a reality.

Citations Report - Journal of Clinical and Cellular Immunology | 50

Improvements in haemopoietic stem cell transplantation and now gene therapy, albeit still only available in the research setting, are improving long-term survival in primary immunodeficiencies. Biologic therapeutic agents are improving the control of autoimmune disease but potentially leading to secondary immunodeficiency, increasing the risk of opportunistic infection and malignancy.

It is an exciting time. National Center for Biotechnology Information , U.


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    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50
    Advances in Immunology: 50 Advances in Immunology: 50

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